The game is a beat-em up that supports up to 4 players. Players can play as Megamind, Minion, Metro Man and Tighten as a starting point for how the game will be.

However, when beating each level, players have the opportunity to choose characters that were not featured in the final version of the film, such as Destruction Worker, Psycho Delic, Conductor, Judge Sludge, and Hot Flash, who are known as Doom Syndicate in the game.



After Megamind becomes the hero of Metro City, he forms his own superhero team, The Mega Squad, to defend the city from the Doom Syndicate.

During this time, the more villains he defeats, the more villains join the Mega Squad. After defeating the Ruler, the last of the Doom Syndicate, chaos is averted and order is restored. Megamind is victorious.



Characteristics:
- Switch between blasters on the fly which become more powerful the more they are used.
- Create a "Mega Squad" of 4 players, choosing from 9 characters, including Megamind.
- Team up with 1-4 players to defend the city against the Doom Syndicate.
- Use super abilities to fight Mega Villains and boost your action with power ups.
- Track and defeat your enemies with Mega Essence Tracker and Bio Essence Neutralizer.